M. Sc. - I (Semester-II) Organic Chemistry-II

M. Sc. - I (Semester-II) Organic Chemistry-II
Paper No. HCT - 202

Unit-I
(a) Study of following reactions with mechanism:                                                                (7)
Dieckmann, Benzoin, Favorskii reaction, Reimer-Tieman, Stobbe, Diels-Alder, Robinson annulation, Chichibabin, Simon- Smith, Ullmann, Mc. Murry and Dakin.

(b)Reagents in organic syntheses:                                                                                          (8) Complex metal hydrides, LDA, dicyclohexylcarbodiimide(DCC), PTC, crown ethers, Merrifield resin, Peterson’s synthesis, 1,3-dithiane, diazomethane, DDQ.

Unit – II
(a) Reduction:                                                                                                                           (7)
Study of following reductions: Catalytic hydrogenation using homogeneous and heterogeneous catalysts. Study of following reactions: Wolff-Kishner, MeerweinPondorffVerley, Birch, Clemmensen, Sodium borohydride, Lithium Aluminium hydride (LAH) and Sodium in alcohol.

(b) Oxidation:                                                                                                                            (8) Application of following oxidizing agents: KMnO4, chromium trioxide (Jone’s reagent, PCC, PDC), Manganese dioxide, Osmium tetraoxide, Oppenauer oxidation and Lead tetra-acetate., Hydrogen peroxide, Baeyer-Villiger oxidation, Prevost-Woodward hydroxylation by silver oxide.

 Unit – III 
(a) Study of Organometallic compounds:                                                                                (8)
 Organo-magnesium, Organo-zinc, Organo-lithium, organo-copper and organo-tin reagents. Addition reactions: Additions to carbonyl and unsaturated carbonyl compounds, Witting reaction.

(b) Methodologies in organic synthesis:                                                                                   (7)
Ideas of synthons and retrones, functional group transformation and interconversions of Simple functionalities.

 Unit – IV
(a) Hydroboration: Mechanism and synthetic applications                                                   (5)
(b) Enamines :Formation and reactivity of enamines                                                             (5)
(c) Protection of functional group: Principle of protection of alcohol, amine, carbonyl and carboxyl group.                                                                                                                           (5)

RECOMMONDED BOOKS;

 1. Modern synthetic reactions-(Benjamin) H. O. House.
2. Reagents in organic synthesis-(John Wiley) Fieser and Fieser
3. Principles of Organic synthesis-(Methuen) R. O. C. Norman
4. Hydroboration- S. C. Brown.
5. Advances in Organometallic Chemistry- (A.P.)F. C. A. Stone and R. West.
6. Organic Chemistry (Longman)Vol. I & Vol. II- Finar
7. Oxidation by-(Marcel Dekker) Augustin
8. Advanced Organic Chemistry 2nd Ed. R R. Carey and R. J. Sundburg.
9. Tetrahedron reports in Organic Chemistry- Vol.1, No. 8.
10. Organic Synthesis-(Prentice Hall)R. E. Ireland.
11. Homogeneous Hydrogenation-(J. K.) B. R. James.
12. Comprehensive Organic Chemistry- (Pargamon) Barton and Ollis.
13. Organic reactions- various volumes- R. Adams.
14. Some modern methods of Organic synthesis-(Cambridge) W. Carruthares.
15. Advanced Organic Chemistry – J. March
16. Lehninger’s Principles of Biochemistry,(4th Ed. ) David L. Nelson, Michael M. Cox
17.Organic synthesis – Jagdambasingh and L. D. S. Yadav   

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