M.Sc.I

Unit-I (a) Study of following reactions with mechanism: 1. Dieckmann  Condensation ( Dieckmann Reaction ): The base-catalyzed intramolecular condensation of a diester. The Dieckmann Condensation works well to produce 5- or 6-membered cyclic ß-keto esters, and is usually catalysed by sodium alkoxide in alcoholic solvent. Mechanism of Dieckmann Condensation 2. Benzoin Condensation (  Benzoin Reaction ): The Benzoin Condensation is a coupling reaction between two aldehydes that allows the preparation of α-hydroxyketones. Mechanism of Benzoin Condensation 3. Favorskii reaction: Favorskii Rearrangement is a base catalysed organic reaction which converts  α -halo ketones or cyclopropanones to carboxylic acid derivatives. If the reaction involves cyclic  α -halo ketones, then ring contraction will take place during rearrangement. This reaction is named after Russian chemist Alexey Yevgrafovich

M. Sc. - I (Semester-II) Organic Chemistry-II Paper No. HCT - 202 Unit-I (a) Study of following reactions with mechanism:                                                                 (7) Dieckmann, Benzoin, Favorskii reaction, Reimer-Tieman, Stobbe, Diels-Alder, Robinson annulation, Chichibabin, Simon- Smith, Ullmann, Mc. Murry and Dakin. (b)Reagents in organic syntheses:                                                                                           (8) Complex metal hydrides, LDA, dicyclohexylcarbodiimide(DCC), PTC, crown ethers, Merrifield resin, Peterson’s synthesis, 1,3-dithiane, diazomethane, DDQ. Unit – II (a) Reduction:                                                                                                                            (7) Study of following reductions: Catalytic hydrogenation using homogeneous and heterogeneous catalysts. Study of following reactions: Wolff-Kishner, MeerweinPondorffVerley, Birch, Clemmensen, Sodium borohydride